Myc Proto-Oncogene protein (MYC) Peptide
MYC
Reactivité: Humain
Hôte: Synthetic
BP, WB, IHC
N° du produit ABIN980418
Aperçu rapide pour Myc Proto-Oncogene protein (MYC) Peptide (ABIN980418)
Antigène
c-MYC (MYC)
(Myc Proto-Oncogene protein (MYC))
Origine
Humain
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB), Immunohistochemistry (IHC)
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Attributs du produit
- This is a synthetic peptide designed for use in combination with anti-MYC antibody (Catalog #: ARP38156_T100). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Indications d'application
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Conseil sur la manipulation
- Avoid repeated freeze-thaw cycles.
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Stock
- -20 °C
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Stockage commentaire
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- c-MYC (MYC) (Myc Proto-Oncogene protein (MYC))
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Sujet
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MYC is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this MYC gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma.The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene.
Alias Symbols: MRTL, c-Myc, bHLHe39
Protein Interaction Partner: E2F1,E2F4,E2F5,CHUK,ESR1,FUBP1,NCOA3,ORC2L,POLR2A,XRCC5,BRCA1,CDK4,CDKN1A,CDKN1A,CDKN1A,CDKN2A,CSNK2A1,DDB2,DNMT3A,FBXW7,FBXW7,KAT2A,MAPK3,MAX,MIR17HG,MLH1,MYCBP2,NCL,NFYB,NFYC,NMI,NPM1,PARP10,PMAIP1,PML,RIBIN,RRM2B,SP1,SP1,TAF1A,TAF1B,TAF1C,TBP,TRRAP,ACTL6A,BCL2,BIN1,BRCA1,CCNT1,CDC6,CDK1,CDKN2A,CEBPA,CEBPB,CREBBP,CSNK2A1,CSNK2A2,DNMT3A,ELF3,EP300,FBXW7,GSK3B,GTF2F1,GTF2I,HSP90AA1,KAT2A,KAT5,MAP2K1,MAPK3,MAPK7,MAPK8,MAX,MINA,MLH1,MXD1,MXI1,MYCBP,MYCBP2,NFYB,NFYC,NMI,PARP10,PFDN5,PML,PRDX1,RAF1,RAGE,RB1,RBL1,RELA,SKP2,SMAD2,SMAD3,SMARCB1,SNIP1,SP1,SPAG9,SUPT3H,TAF1B,TBP,TFAP2B,TIAM1,TP73,TRRAP,TUBA1A,TUBA1B,TUBA3C,TUBA4A,TUBA8,UBB,YY1,ZBTB17,ACTB,ACTL6A,ARHGEF2,BCL2,BRCA1,BRD7,CCNT1,CD6,CDC6,CDK9,CEBPA,CEBPB,DDX24,DNMT3A,EFTUD2,EP400,EXOC4,Eif4e,FANCI,FBXW7,GCN1L1,GEMIN4,GTF2B,GTF2F1,GTF2I,GTF3C3,HEATR1,HNRNPC,HSP90AA1,KAT2A,KAT2B,KAT5,KIAA1967,MAPK1,MAPK3,MAPK8,MAX,MCM7,MED12,MED14,METTL13,MKLN1,MLH1,MSH2,MSH6,MYBBP1A,MYCBP,MYCBP2,MYO1B,NFYB,NFYC,NMI,NUP205,NUP93,PDS5A,PFDN5,PIAS2,POLE,POLR2A,PRPF8,RAF1,RB1,RBL1,RELA,RUVBL1,RUVBL2,SAP130,SMAD2,SMAD3,SMARCA4,SMARCB1,SNRNP200,SP1,SUPT3H,TADA2A,TADA3,TAF10,TAF12,TAF5,TAF5L,TAF6L,TAF9,TBP,TFAP2A,TIAM1,TP73,TRRAP,UBB,YY1,ZBTB17
Protein Size: 170 -
Poids moléculaire
- 19 kDa
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ID gène
- 4609
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NCBI Accession
- NM_002467
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UniProt
- P01106
Antigène
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